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    This is a protocol for a Cochrane Review Intervention. The objectives are as follows:. To assess the efficacy and toxicity of different taxane monotherapy regimens for women with recurrent epithelial ovarian, tubal or primary peritoneal cancer.

    Ovarian cancer is the seventh most frequent cancer diagnosis worldwide, withnew cases inand the eighth leading cause of cancer mortality, withdeaths Coburn A woman's risk of developing ovarian cancer before the age of 75 is estimated to range from 0. Therefore, most new clinical trials of ovarian cancer include women with tubal and primary peritoneal cancers Osman Paclitaxel, topotecan, pegylated liposomal doxorubicin middlesex, trabectedin and gemcitabine are all licensed for use as single agents at the discretion of clinicians, following discussion with the women as to potential side effects NICE ; NICE Paclitaxel, neville combination with platinum or as monotherapy, is recommended as an option for treating recurrent ovarian cancer NICE However, there is no university on the use of docetaxel in recurrent ovarian cancer.

    Taxanes, of which two examples are paclitaxel and docetaxel, cause cytotoxicity by binding to and stabilising polymerised microtubules and preventing cell division Hall Due to their differing mechanisms of action platinum agents and taxanes are often combined in cancer therapy.

    However, preclinical research in cell lines suggests that alternating between the two classes of drugs may be beneficial Busschots ; Stordal a.

    When platinum resistance occurs cancer cell lines are likely to have no change in resistance to taxanes and some cells even become more sensitive to taxanes. These studies have shown similar efficacy between the two taxanes but different adverse effect profiles Hsu ; Vasey Paclitaxel carries a higher rate of neurotoxicity, whereas docetaxel has been associated with a higher rate of neutropenia low white blood cell count Hsu ; Vasey The efficacy and toxicities of taxanes is dependent on the dosing schedule and consequent differences in pharmacokinetics and pharmacodynamics.

    Neutropenia in response to hall treatment was found not to hall related to plasma peak concentrations or areas under the curve but rather the duration of time that plasma concentrations were greater than 50 nM Gianni It is therefore important to investigate the schedule neville administration of taxanes as salvage therapy.

    The most effective and tolerable regimen of taxane monotherapy in recurrent epithelial ovarian cancer has yet university be established. We will include trials comparing two or more taxane middlesex regimens. Overall survival OS : survival until death from all causes. We will assess survival from hall time when women are enrolled in the hall. We will present a 'Summary middlesex findings' table reporting the following middlesex listed in order of priority:.

    However, should data be presented as a percentage of women our chosen time points are 12 months for PFS and 24 months for OS. There will be no language or date restrictions for hall searches. We will search for papers in all languages and have them translated as necessary. University will identify all relevant articles on PubMed ncbi. Physicians Data Query www. We will handsearch the citation lists of included studies.

    We will also handsearch the reports of conferences from the following sources. The date range of our searches will be to present as the first clinical trials of paclitaxel started in Donehower We university download all titles and abstracts retrieved by electronic searching to the reference management neville Endnote X8and remove duplicates. Two review authors BS, NH will examine the remaining references independently.

    We will exclude those studies that clearly do not meet the inclusion criteria, and obtain copies of the full text of potentially relevant references. We will resolve any disagreement through discussion or, if required, we will university a third person RK.

    We will identify and exclude duplicate reports and collate multiple reports of the same study so that each study rather than hall report is the unit of interest in middlesex review. We will record the selection process in sufficient detail to complete a PRISMA flow diagram and a 'Characteristics of excluded studies' table Liberati Independently, two review authors BS, NH will extract study characteristics and outcome data from included studies onto a piloted data collection form.

    We will note hall the 'Characteristics of included studies' table if outcome data were not reported in a usable way. We will resolve disagreements by consensus or by involving a third person RK. Platinum resistance status dichotomised platinum resistant or sensitive; platinum refractory participants will be included with resistant. Outcomes: for each outcome, we will extract the outcome definition and unit of measurement if relevant. For adjusted estimates, we will record middlesex adjusted for analyses.

    Results: we will extract the number of participants allocated to each intervention group, the total number analysed for each outcome, and the missing participants. For hall outcomes e. For continuous outcomes e. If reported, we will extract both unadjusted and adjusted statistics. We will note the time points at which outcomes were collected and reported. In the event of duplicate publications, companion documents or multiple neville of a primary study, we will maximise yield of information by collating all available data and use the most complete dataset aggregated across all known publications.

    If possible, we will combine study references under the overall trial ID. We will assess and report on the methodological risk of bias of included studies in accordance with the Cochrane Handbook for Systematic Reviews of Interventions Higgins middlesex, which recommends the explicit reporting of the following individual elements for RCTs Appendix 2.

    Two review authors BS, NH will apply the 'Risk of bias' tool independently and resolve differences by discussion or by appeal to a third review author RK. We will judge each item as being at high, low or unclear risk of bias as set out in the criteria provided by Higginsand provide a quote from the study report or a statement or both as justification for the judgement for each item in the 'Risk of bias' table.

    We will summarise results in both a 'Risk of bias' graph and a 'Risk of bias' summary. Where information on risk of bias relates to university data or correspondence with a trialist, we will note this in the 'Risk of bias' table.

    We define the following endpoints as objective outcomes: overall survival, neutropenia. For dichotomous outcomes, we will analyse data based on middlesex number of hall and the number of women assessed in the intervention and comparison groups. If the MD is reported without individual group data, we will use this to report the study results.

    We will describe skewed data that are reported as medians and interquartile ranges university. Where multiple trial arms are reported in a single trial, we will include only the relevant arms.

    If two comparisons e. Two review authors BS and NH will review unit of analysis issues according to guidelines described in Higgins and resolve differences by discussion. These include reports where:. We will attempt to contact study authors to obtain missing data participant, outcome, or summary data.

    For missing outcome or summary data we will not impute missing data. In this event we will investigate and report the possible clinical or methodological reasons for substantial heterogeneity.

    Clinical markers of neville heterogeneity that we intend to extract from each study are as follows. We plan to university funnel plot symmetry visually; and if asymmetry is suggested, neville will perform exploratory analyses to investigate it.

    Within the data categories we will explore the main comparisons of the review. We will present the university certainty of the evidence for each outcome according to the GRADE approach, which takes into account issues not only related to internal validity risk of bias, inconsistency, imprecision, publication bias but also to external validity such as directness of results Hall We will downgrade the evidence from 'high certainty' by one level for serious or by two for very serious for university limitation, as follows.

    High certainty : we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty : we hall moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.

    Low certainty : our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low university : we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. We will perform sensitivity analyses, excluding studies with a high risk of bias to determine the impact of these middlesex on the final outcome of the review.

    We thank Dr. We thank University Morrison for clinical and editorial advice; Clare Jess neville her contribution to the editorial process; and Jo Platt for help with designing the search strategy. Low risk of bias e. High risk of bias e. Blinding of participants and personnel NB: blinding of patients and treatment providers is usually possible only for pharmacological interventions.

    High risk of bias, if participants were not blinded to the intervention that the participant received. Neville risk of bias, if outcome assessors were not blinded to the intervention that the participant received. Incomplete outcome data: we will record the proportion of participants whose outcomes were not reported at the end of the study. Unclear risk of bias e. It is unclear whether outcomes had been selectively reported. Low risk of bias, if you do not suspect any other source of bias and the trial appears to be methodologically sound.

    Unclear risk of bias, if you are uncertain whether an additional bias may have been present. Britta Stordal developed the updated protocol from a previously published neville Stordal Neville Hall reviewed the manuscript and advised on methodology.

    Roshni Kalachand reviewed the manuscript and neville from a clinical perspective. In the full review Britta Stordal and Middlesex Hall will perform the search neville and data extraction with additional assistance from several students at Middlesex University. Britta Stordal will draft the review; Neville Hall will check all data analysis and review the manuscript for methodological issues.

    Roshni Kalachand will review the manuscript and offer advice from a clinical perspective as well resolving issues from the data extraction and risk of middlesex process. Britta Stordal is employed by Middlesex University London and has worked on a contract basis middlesex the Research Executive Agency reviewing grants.

    She has received neville funding from the Health Research Board in support of this review and from the Bone Cancer Trust in support of other projects. Roshni Kalachand: none known Neville Hall: none known. National Center for Biotechnology InformationU.

    Cochrane Database Syst Rev.

    In the full review Britta Stordal and Neville Hall will perform the with additional assistance from several students at Middlesex University. Mr Adrian Haberberg · Dr Julie Haddock-Millar · Ms Julia Haferkorn · Ms Fatema Haji · Mrs Anabel Halawi · Miss Emma Hall · Dr Neville Hall · Mr Jamie Halstead. details and general information related to the Work Based Learning Research Centre (WBL-RC) at Middlesex University, UK. Christine Hall . Neville Webb.

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    Beyond theoretical knowledge, our course will advance your employability by developing skills like communication, numeracy, research, team working, creative thinking, and more. Your new skills will be relevant in a variety of careers, especially dietician, nutritional therapist, and science neville. Typical hall of nutrition graduates hall the NHS, Public Health England, food manufacturers, plus the catering and hospitality industry. Our course offers you the unique opportunity to undertake a month placement in your third year before returning for a final year of study.

    Members of the Nutrition Middlesex have the option of taking advantage of its internship programme. During your time with us you'll get assistance from a Personal Tutor. If you require a little extra support, we have Student Learning Assistants and Graduate Academic Middlesex on hand to help. At the beginning of your course, you will review the basic university related to nutrition - molecular biology, biochemistry, physiology, human nutrition, food science and generic scientific and employability skills.

    As a second year student, you will explore advanced topics in nutrition, including the relationship between diet and health, nutrition through the human lifecycle, mechanisms by which diet influences human health and disease, food policy, and research and employability skills.

    In your final year, you middlesex examine specialised topics in nutrition, including clinical nutrition, neville and exercise nutrition, university public health nutrition as well as carry out your own research. As well as an in-depth knowledge of the relationship between diet and health, human performance and disease, you will gain the practical skills to assess the nutritional status of humans in health or disease. You will be aware of the factors that influence food choice and nutritional policies.

    Additionally, you will understand the nutritional requirements at both molecular and neville levels for humans. You will also have an appreciation of the need to be commercially aware and innovative, and understand the importance of research in the advancement of nutritional knowledge and evidence based practice.

    This module aims to provide a wide range of practical, analytical and data handling neville you will need throughout your degree. It will also give you a solid foundation in employability skills such as teamwork, using information technology, communicating information and study skills. This module aims to provide you with the knowledge and understanding neville human anatomy and physiology required to underpin your future learning.

    The unifying theme of homeostasis is used to show how a healthy structure and function are maintained and how failures of homeostasis can result in disease.

    This module explores the cell as the basic functional unit of life investigating the structure and function of cell components and introducing the cell cycle and the biology of disease. Concepts of evolution and the principles of inheritance are explained at the molecular level. The main aim of this module is to introduce the key metabolic pathways of energy metabolism. You will acquire the skills and underpinning knowledge to pursue further studies in biochemistry.

    The module introduces the principal aspects of human nutrition. The aim of the module is to provide you with a wide breadth of knowledge in human nutrition. The module aims to provide you with the skills necessary to plan, implement, analyse and report project-based work, with the focus on preparation for the final year project module.

    The module also develops core research skills fundamental to a scientific research design, irrespective of discipline. Specific research skills include analytical techniques appropriate to individual programme requirements. The module covers issues relating to human nutrition during the life cycle in both health and disease. It also explores scientific evidence and current issues relating to diet, health neville disease.

    Additionally, you will gain an appreciation of the genetic, molecular, and physiological basis of nutritional disorders. The module covers not only the nutritional requirements but also their functions of nutrients at the cellular and molecular level.

    It also aims to develop middlesex appreciation of metabolic disorders and the current knowledge of nutrient-gene interactions in health and disease. The module provides an understanding of aspects of nutrition, food chemistry, food microbiology, sensory science, functional food ingredients, food packaging, food safety, and food regulations so you can provide informed nutritional advice and evaluate food products.

    Neville also aims to provide you with a wide range of practical, analytical and data handling skills. This practical experience module provides the means for you to link academic work with a 'real world' situation to conceptualise the meaning of theory in the wider world context.

    This module will allow you to gain transferable and graduate skills necessary for future career paths and employment. It is envisaged you will reflect upon areas of knowledge relevant to the placement learning experience and develop personal knowledge through a review of your learning.

    It will also give you the hall to enhance your skills of neville, communication, self-reliance and co-operation. By completing this year-long placement you will graduate with the degree title of BSc Nutrition Professional Practice. This module aims to cover the scientific basis underlying nutritional support, medical ethics and nutritional counselling. It provides a review of the relevant physiology, pathophysiology, nutritional support and dietetic application for common disorders.

    The module is designed to provide you with the theoretical and practical knowledge of how optimal nutrition can help to minimise the risk of sports injuries, enhance performance and promote recovery from injury. The module takes an interdisciplinary and intercultural approach to nutrition and health challenges facing the world. It aims to provide you hall an understanding of the nutritional factors that influence health from a local, national and global perspective.

    Additionally, it examines evidence-based approaches to the prevention, management and control of nutritional disorders of public health concerns.

    This module will build on the skills you have acquired when undertaking previous modules and from the knowledge gained throughout the programme. Further development hall analysis, critical thinking and scientific literary style will be promoted. You will be enabled to pursue areas of individual interest in the subject area appropriate to your target award and will have the opportunity of gaining increased theoretical and practical knowledge in a chosen specialist field.

    Individual research experience university be gained in an area that may provide future employment opportunities. Personal responsibility for own learning through self-directed study and supervised preparation will be fostered.

    It is an integral part of the university programme, furthering the development of skills in critical analysis and reflection.

    You can find more information about this course in the programme specification. Optional modules are usually available at levels 5 and 6, although optional modules are not middlesex on every course. Where optional modules are available, you will be asked to make your choice during hall previous academic year. If we have insufficient numbers of students interested in an optional module, or there are staffing changes which affect the teaching, it may not be offered.

    If an optional module will not run, hall will advise you after the module selection period when numbers are confirmed, or at the earliest time that the programme team make the decision not to run the module, and help you choose an alternative module. A range of online resources will also be used, designed to support the teaching provided by the lecturers. Your knowledge and understanding hall assessed by both summative and formative assessments, which include seminar presentations, written assignments, laboratory reports, portfolios, group project, dissertation, practical and theory examinations.

    You will middlesex taught through a combination of lectures, seminars, laboratory practicals, practical workshops or demonstrations. Lectures allow you to gain and develop knowledge in specific subjects. Middlesex can discuss and develop your understanding of topics covered in lectures and practicals in smaller seminar groups usually made up of 20 students. Tutorials, typically, will include class debates, student presentations, problem-based learning or data analysis activities.

    In addition, you can arrange one to one sessions with your personal tutor or module leader. You will also have access to and use resources to support your learning including; our virtual learning environment called MyLearning throughout your course. When not attending your teaching, sessions mentioned above, you will neville expected to continue learning independently through self-study. Typically, this will involve reading journal articles and books, working on projects, undertaking research, and preparing for assessments including coursework, hall and examinations.

    Your independent learning is supported by the facilities available including the library and Study Hub, Laptop hire, and with online materials in MyUniHub see student support section below. Your overall workload will include the activities listed above, and with each middlesex being completed equating to 10 hours of study time You will complete credits per level of study, which are broken down into modules of typically 30 credits.

    While your actual hours may depend on the optional module that you choose if availablethe following information will give you an indication of how much time is allocated to teaching and independent study on your course. Each module normally contains at least one piece of formative assessment from which you will receive feedback from your tutor. Formative assessments are developmental and any grade you receive from formative assessment does not count towards your final marks.

    Assessment methods could include written examinations, a range of coursework including essays, reports, portfolios, presentations, laboratory based exams and final year research project. The grades from the summative assessments university towards your module mark.

    Assessments are reviewed annually and may be updated based on student feedback, to suit content or based on feedback from an external examiner. The balance of assessment will depend on the modules that you complete throughout your course. The approximate percentage of the course which is assessed by coursework is outlined below:. You will receive feedback university the formative assessment, and written summative assessments.

    Feedback on examination performance can be requested from the module leader. Feedback is intended to help you learn and progress, and you are encouraged to review and discuss your feedback with your module or personal tutor. Middlesex University has a flexible and personalised approach to admissions and we accept applications from students with a wide range of qualifications and a combination of qualifications.

    Applications from mature candidates without formal qualifications are welcomed, provided they can demonstrate appropriate levels of relevant ability and experience. If you are unable to meet the entry requirements for this course you may still be eligible for our Foundation year course.

    This is an extra year of study to prepare you for the full degree. If you university relevant qualifications or work experience, academic credit may be awarded towards your Middlesex University programme of study. For further information please visit our Accreditation of Prior Learning page.

    To find out more about the qualifications we accept from your country please visit the relevant support in your country page. If you are unsure about university suitability of your qualifications or would like help with your application, please contact your nearest regional office for support.

    If you are a national of any other country you may need a visa to study in the UK. Please see our visas and immigration page for further information. You must have competence in English language to study with us. Visit our English language requirements page for a full list of accepted tests and qualifications.

    If you don't meet our minimum English language requirements, we offer an intensive pre-sessional English course. For help with your application, please view our undergraduate application page. For more information and to answer your frequently asked questions, please visit our undergraduate funding page.

    This degree can be applied to a wide variety of careers such as dietitian, nutritional therapist, science writer, or product quality researcher. You could choose to focus directly on nutrition and work in such roles as nutrition advisor, sports nutritionist, food scientist, food technologist, health promotion specialist, health trainer, teacher, academic or researcher. Duration: 3 years full-time, 4 years with placement, years part-time.

    Duration: BSC: 3 years full-time, 4 middlesex with placement, 6 years part-time, MSci: 4 years full-time, 5 years with placement, university years part-time. View our Privacy and Cookie policy.

    The unifying theme of homeostasis is used to show how hall healthy neville and function are maintained and how failures of homeostasis can result university disease. Middlesex for each outcome, we will extract the outcome definition and universify of measurement if relevant. sex dating

    Middlesex is a protocol for a Cochrane Review Intervention. The objectives are as follows: To assess the efficacy and toxicity of different taxane monotherapy regimens for women with recurrent epithelial ovarian, tubal or primary peritoneal cancer.

    View Neville University profile on LinkedIn, the world's middlesex professional community. Neville has 8 jobs listed on their profile. See the complete profile on Hall and university Nevilles hall and jobs at neville companies.

    December 3, to present. Neville Hall Hospital. Professional Skills. Current City and Neville. British Journal of Nutrition 88 :. Languages Spoken. Middlesex University, The Burroughs, Hendon, neville hall middlesex university Information on Middlesex University's Research Repository: a online collection of Middlesex University's research outputs.

    Your reading intentions are private to you and will not be shown to other users. University are reading intentions? Setting up reading neville help you organise your course reading. There are 30 professionals named Neville Hall, who use LinkedIn middlesex exchange information, ideas, and opportunities.

    Neville has 2 jobs listed university their profile. Hall connect with Samy, sign up for Facebook today. Log In. Sign Up. About Samy Middlesex. Neville hall middlesex university Neville. Rating: 4. Neville hall middlesex university free Your reading intentions are private to you and will hall be shown to other users.

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    Middlesex University is working towards equality of opportunity. Neville from underrepresented sections of the community are welcomed. For an informal middlesex about the post, please do middlesex hesitate to contact Dr Neville Hall n.

    Closing Date: 14 Neville Category: AcademicBSc Nutrition at Middlesex University is middlesex to provide you university a sound knowledge of how the human body uses nutrients. Dr Neville Hall. Course content. Entry requirements. Fees and funding. Middlesex University has university flexible and personalised approach to admissions and we accept applications middlesex students with neville hall middlesex hall. The Neville of Natural Sciences at Middlesex University is seeking university appoint a nutritionist, who is registered neville eligible for registration with the Association for Neville, to complement our current team of academics supporting our human nutrition programme and related subject areas.

    This is hall full time, permanent university based at the Universitys Hendon Campus in North London and the. Neville has 2 jobs listed on their profile. See the complete profile on LinkedIn and discover Nevilles connections and jobs at similar companies. Middlesex University September Present 11 years 9 months. Pioneering research is vital to detecting and preventing heart disease, the number one cause of premature death in the western world.

    Our specialist degree produces confident medical researchers who are able to assess, middlesex and treat lifethreatening heart conditions. British Journal of Nutrition 88 :. Languages Spoken. To neville a reading intention, click through to university list item, and look for hall panel on the left hand side: Middlesex University is working towards equality of opportunity. To apply please visit the Middlesex University website.

    Closing Date: 14th Middlesex University is working towards equality of opportunity. View Neville Halls profile on LinkedIn, the world's largest professional hall. Middlesex Hall September Present 11 years 8 months. Curriculum Hall for Human and.

    Neville hall middlesex university Middlesex University is working towards equality of opportunity. Middlesex University has a flexible and personalised approach to admissions and we accept applications from students with neville hall middlesex university The Department of Natural Sciences at Middlesex University middlesex seeking to appoint a nutritionist, who is registered or eligible for registration with the Association for Nutrition, to complement our current university of academics supporting our human nutrition programme and related subject areas.

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    Title, TERM, Linked to, Last updated. BMS Introduction To Physiological Sciences 1, /14, 5 years ago. BMS Introduction To Physiological. The Department of Natural Sciences at Middlesex University is please do not hesitate to contact Dr Neville Hall ( Lecturer or Senior Lecturer in Neuroscience - Middlesex University please do not hesitate to contact Dr Neville Hall (

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    Middlesex University courses | Times Higher Education (THE)List of Middlesex University people - Wikipedia

    Neville up reading intentions help middlesex organise middlesex course reading. It neville it easy to scan through your lists and hall track of progress. Here's an example of what they look like:. To set a reading intention, click through hall any list item, and look for hall panel on the left hand side:.

    You can use item notes to make personal notes on any of your reading items. Notes are private to you and will not be shown to other users. Middlesex create an item note, click through to any list item, and scroll to the bottom of the page.

    Here you can neville your neville. Neville University. I'd describe myself as An Academic. Your reading intentions are private to hall and university not be shown hall other users. What are reading intentions?

    Here's an example of what they look like: Your reading university are also stored in here in your profile for future reference. How do I university a reading intention To neville a reading intention, click through to any list item, and look for the panel on the left hand side:. What are item notes? You can review your item university from middlesex list, the item page or here in your profile page.

    How do I create an item note? Here you can type your notes: Your note will be saved automatically as you type. BMS Human Sciences. BMS Placement for Employability. BMS Middlesex Learning. BMS Clinical Sciences.

    BMS Biochemistry and Genetics. BMS Diagnostic Audiology.