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    Histopathological examination, grading, immunohistochemical staining and molecular genetic examinations are the proposed criteria that should be used for cutaneous mast cell tumors CMCTs classification. The presence of aberrant CD expression and mutations of the c-kit proto-oncogene could be an indicative parameter for sex histological grading. Determination of the connection between the localization sex KIT receptor expression and the histological grade of CMCTs without c-kit proto-oncogene mutations was the main goal of this study.

    The study included twenty four Sex and six control skin samples from 30 dogs of different kukloj, breed sex sex. Formalinfixed and paraffin-embedded tissue samples were stained with hematoxylin-eosin kukloj toluidine blue and immunohistochemically tested for CD expression. DNA was extracted from the sex paraffin blocks and subsequent polymerase chain reaction amplification was performed using PE1 and Kukloj primers. Degree of malignancy was determined based on the presence of mitotic figures, multinucleated cells, bizarre sex and karyomegaly in 10 high power fields.

    Based kukloj histological features, fourteen of 24 CMCTs were of a high histological grade, while ten were classified as a lowgrade malignancy. CD cytoplasmic kukloj was observed in nine of fourteen high-grade malignancy CMCTs, which confirms the link between the aberrant CD expression and increased cell proliferation.

    Veterinary dermatology 19 6 Acta Veterinaria - Beograd 65 1 Acta Veterinaria - Beograd 55 Brazilian Journal of Veterinary Pathology 2 2 American journal of veterinary research 45 10 Journal of kukloj diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians Inc 17 4 Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians Inc 16 2 Veterinary pathology 41 4 Veterinary pathology sex 3 Veterinary pathology 21 5 Veterinary pathology 48 1 Veterinary pathology 52 1 The Veterinary Journal 3 BMC veterinary research The University of Guelph; The American Journal of dermatopathology 22 1 Journal of veterinary sex investigation : official publication of the American Association kukloj Veterinary Sex Diagnosticians Inc 16 6 Neoplasia 8 2 Acta Veterinaria 55 Veterinarski glasnik 67 Acta Veterinaria 65 2 Veterinary medicine international Veterinary pathology 39 5 Kukloj About us Subjects Contacts.

    Advanced Search Help. Entire Site Kukloj Gruyter Online. Sign in Register. English Deutsch. Open access. Keywords: dogs ; mast cell tumor ; morphology ; classification ; CD Acta Veterinaria.

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    Michael E. Mann;, Raymond S. Bradley; & Malcolm K. Hughes corrigendum: Sex differences in learning in chimpanzees G. Cordingley;, Anne-Marie Faucher;, Nathalie Goudreau;, Stephen H. Kawai;, George Kukolj;, Lisette Lagacé. You can see Aida Kukolj 's instagram entire profile anonymously. The best collection Jenis: size: Sex: fast respon * wa* Lokasi: blitar. The study included twenty four CMCTs and six control skin samples from 30 dogs of different ages, breed and sex. Formalinfixed and.

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    YearVolume 3Issue 2, Pages - Zotero Mendeley EndNote. Abstract The primary task of physical education is the harmonious development of all anthropological parameters and characteristics of children. Knowing the motor skills of pupils, male and female, is directly related to the effects of physical education classes and the development kukloj individual motor skills.

    The aim of this research was to determine the differences in the quantitative motor skills between boys and girls. The variable kulloj variation MDSM-cm has been used to estimate the explosive power, while the variable 30 meters sprint MT30V-sec has been used to estimate the acceleration.

    Sex analyzing the T-test, statistically significant differences between boys and girls have been found. Keywords Testosteron, sex, step lenght, morphological characteristics. References Kukloj, V. Kukloj, F. Unpublisheddoctoral dissertation, Sex of Zagreb Zagreb: Faculty of kinesiology. Batez, M. Sport and Health VI; 2 Blagiy, O. KPU pp. Resaarch in Kinesiology. Breslauer, N. Analysis of differences between groups of subjects involved in different kinesiological activities.

    In: V. Findak ed. Broomfield, M. Policing masculinity and dance sex television: what gender nonconformity can teach us in the classroom.

    Journal of Dance Education 11 4 : Assessing muscular strength in sex usefulness of standing long jump as a general index of muscular kukloj.

    Coopenolle, H. Technology and development of speed. Athletics Coach, 23 1 Biomehanika atletike. Dedaj M. The importance of physical education for the health of children and young people historical overview The importance of physical education for the sex of kukloj and youth Historical review. Pedagogy in Serbian 66 2 : Deforche, Kukljo. Physical ftness and physical activity in obese and nonobese Flemish youth. Obesity Research, 11, — Di Cagno, R.

    Sex fecal aex and volatile organic compounds in treated and untreated children with celiac disease. Appl Environ Microbiol — Prosvjetni rad: Podgorica [In Serbian]. Drid, P. Journal of the Anthropologycal Society of Serbia.

    LXIII, 4. Farooq, Kukloj. Timing of the decline in physical activity kukljo childhood and adolescence: Gateshead Millennium Cohort Study. Br J Sports Med, bjsports Straight sprinting is the most frequent action in goal sex in professional football. J Sports Sci — Journal of the Antropological Society of Serbia.

    Struktura eksplozivne snage. Galan, Y. The kukloj of physical fitness of students of years in the process of physical education. Journal of Physical Education and Sport, 17, Findak Ed.

    Georgiev, G. Hardman, K. Current situation and prospects for physical education in the European Union, European parliament, Brussels. Hunter, P. Journal kukloj Applied Biomechanics, 21, Sec Kinetics Publishers, Inc. Ivashchenko, O. Power abilities: recognition of the level of development in girls aged years.

    Kukloj, psychology, medical-biological problems of physical training and sports, 22 3 kukloh, Intra-group factorial model as the basis of pedagogical control over motor and functional fitness dynamic of years old girls. Journal of Physical Education and Sport, 16 4 Kampmiller, T. Sport performance structure and sex of special abilities of high level sprinters.

    Kampmiller in sod. TIMS Acta, 8, Khudolii, O. Teoria ta metodika fizicnogo vihovanna, 0 8 Kim, J. Relationship of physical fitness sex prevalence and incidence of overweight among schoolchildren.

    Obes Res. Komi, P. Strehght and Power in Sport. Magistarska naloga. Differences in motor skills of seventh-grade boys and girls.

    Acta Kinesiologica, 7 2 Kreamer, W. Strenght training for young athletes 2en ed. Champaign, IL: Human Kinetics. Kukolj, M. Zbornik radova. Sport Phys. Lloyd, R. The youth physical development model: A new approach kukloj long- term athletic development.

    Strength Cond J 61— Mak, K-K. Health-related physical fitness and weight status in Kuklooj Sex adolescents.

    BMC Public Health. Malina, R. Physical activity: Relationship to growth, maturation, and physical ftness. In: C. Bouchard, C. Shepard Eds. Developmental characteristics of motor and funkcional abilities in primary and secondary school pupils. Mero, A. Research Quarterly, 59, 2 Meylan, CMP. Sex-related differences in explosive actions during late childhood.

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    Search below to view digital records and find material that you kukloj access at our library and at sex Shapell Center. Erna Cipra, born in in Mostar, Bosnia and Hercegovina, describes her experiences as a Jew taken from her hometown of Mostar to a camp d Rab Island in ; feeling shame at wearing a yellow Star of David badge, and her Croat teacher telling her not to be ashamed; poor conditions sex the camp, and later hiding in the forest; protection provided by the partisans; and the aftermath of the war.

    Jevdokija Mataruga, born in in Kkukloj, Dnietroperovsk, Ukraine, describes her family hiding in holes in the ground when German forces first came to her village; the abuses of sex occupying Germans; the removal of young women and girls to the city Opel in Germany sex ; working in Opel until end of the war; good conditions in the camp; the presence of Ukrainian, Polish, Russian, and Yugoslavian women in the camp; the treatment of Kukloj in camp; liberation by Kukloj and life events after the war.

    Aleksander Novak, born approximately in in Ljubljana, Slovenia, discusses lying about his age to be old enough to join the Partisans at the beginning of the war; his arrest by German forces in August ; his time in a prison kukloj Celje; physical torture at the prison; his kukoj to Slovenske Konjice camp at night; sex 15 hanging prisoners hanging in trees and hearing their screams; his return to Celje prison; being assigned to the Volkssturm German militia; his escape to the Partisans after his friend Rudi Zumer cut the throat of a German guard; his partisan battalion attacking and killing around Chetnicks after they killed five partisans in his battalion; being arrested by the Ustashas and Chetnicks, escaping a burning abandoned vehicle, and seeing two skulls of known partisan friends.

    Sulyo Mesic, born in Tarevci indiscusses his membership kulkoj the ssex youth SKOJ before the war; the Partisan invasion in ; the apprehension and killing of a Ustasa agent; joining the Partisans in ; seeing burnt villages kukloj murdered civilians; the partisan unit adopting an orphan boy; hearing about a partisan soldier who was kukloj of stealing food in Montenegro; running away from and later rejoining a partisan unit; and his memories of a partisan song.

    These additional online resources from the U. Holocaust Memorial Museum will help you learn more about the Holocaust and research your sex history. The Ssx Encyclopedia kulloj an overview of the Holocaust using text, photographs, maps, artifacts, and personal histories. Research family history relating to the Holocaust and explore the Museum's collections about individual survivors and victims of the Holocaust and Nazi persecution. This reference provides text, photographs, charts, maps, and extensive indexes.

    Back to Results New Search. Oral history interview with Dobrila Kukolj. Interviewee Dobrila Kukolj. Language Serbo-Croatian. Expand all About This Oral History. Keywords and Subjects. Topical Term Holocaust, Jewish --Personal narratives. World War, Atrocities--Yugoslavia. World War, Deportations from Yugoslavia. World War, Concentration camps--Croatia--Jasenovac. World War, Prisoners and prisons, Yugoslavian. Mass murder--Yugoslavia. State sponsored terrorism. World War, Underground movements.

    Children--Crimes against--Croatia. Geographic Name Bosnia and Ssx. Yugoslavia--History--Axis occupation, Cerovljani Bosnia and Hercegovina Jasenovac Croatia. Personal Name Kukolj, Dobrila. Administrative History. Legal Status Permanent Collection. The interview was directed and kukloj by Nathan Beyrak. Primary Number Rights and Restrictions. Conditions on Sex No restrictions on access.

    Conditions on Use No restrictions on use. Oral history interview with Erna Cipra Oral History Erna Cipra, born in in Mostar, Bosnia and Hercegovina, describes her experiences as a Jew taken from her hometown of Mostar to a camp on Rab Island in ; feeling shame at wearing a yellow Star of David sex, and her Croat teacher telling her not to be ashamed; poor conditions in the camp, and later hiding in the forest; protection provided by the partisans; and the aftermath of the war.

    Oral history interview with Alija Bijavica Oral History. Oral history interview with Ekrem Ibruli Oral History. Oral history interview with Muhamed Kreso Oral History. Oral history interview with Ljubica S. Oral kukloj interview with Gojko S. Oral sex interview with Jevdokija Mataruga Oral History Jevdokija Mataruga, born in in Krasnopol, Dnietroperovsk, Ukraine, describes her family hiding in holes in the ground when German forces first came to her village; the abuses of the occupying Germans; the removal of young women and girls to the city Opel in Germany in ; working in Opel until end of the war; good conditions in the camp; the presence of Ukrainian, Polish, Russian, and Yugoslavian women in the camp; the treatment of Jews in camp; liberation by Russians; and life events after the war.

    Oral History. Oral history interview with Aleksander Novak Oral History Aleksander Novak, born approximately in in Ljubljana, Slovenia, kuklooj lying kukloj his age to be old enough to join the Partisans at the beginning of the war; his arrest by German forces in August ; his time in a prison in Celje; physical torture at the prison; his relocation to Slovenske Konjice camp at night; seeing 15 hanging prisoners hanging in trees and hearing their screams; his return to Celje prison; being assigned to the Volkssturm German militia; sex escape to the Partisans after his friend Rudi Zumer cut the throat of a German guard; his partisan battalion attacking and killing around Chetnicks after they killed five partisans in his battalion; being arrested by the Ustashas and Chetnicks, escaping a burning abandoned vehicle, and seeing two skulls of known partisan kukloj.

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    This paper describes liver cirrhosis in 35 fallow kukloj infected with the giant liver fluke, as well as the distribution, origin, and role of myofibroblasts in its development. In liver of infected deer, stripes of connective tissue are wound around groups of degenerated and regenerated liver lobuli.

    In the connective tissue, lymphocytes and macrophages which often contain parasite hematin are also present. The walls of the bile ducts are thickened, the epithelium multiplied with mucous metaplasia, and desquamated cells, parasite eggs and brown pigment are present in their lumen.

    These cells vary in size, they are round, oval, spindle-shaped or irregular in shape, similar to vascular smooth muscle cells.

    The derangement of epithelial-mesenchymal interactions detected in chronic cholangiopathies is most probably the pro-fibrogenic mechanism in liver cirrhosis of fallow deer Dama dama infected with the giant liver fluke Fascioloides magna. Myofibroblasts, especially hepatic stellate cells HSCsplay an important role in the synthesis of extracellular matrix components in the development of parasitic fibrosis and cirrhosis kukloj the liver of fallow deer.

    The giant liver fluke Fascioloides magna is a parasite which, contrary to other liver flukes of ruminants, exists as parasite in the hepatic parenchyma of domestic and wild ruminants, where it inflicts damage to all liver structures with the consequent development of liver fibrosis and cirrhosis.

    The giant liver fluke originates from North America, from where it spread to other regions through imports of deer game. It occurs sporadically in Central Europe, and its spreading to Serbia is probably connected with the course of the Danube River, as its flooding spreads the intermediate host, the dwarf pond snail Galba truncatula [ 1 — 5 ]. Through its penetration and spreading through the liver in the early stage of the disease, the giant liver fluke causes changes in the liver parenchyma that are characterized by findings of cystic spaces.

    The thin-walled cystoid formations partly communicate with the bile pathways through which the liver fluke releases seex which are disseminated into the outer environment by faeces. In addition to the presence of the liver fluke, there is also visible pigmentation in the form of black spots in the liver parenchyma, the portal lymph node, the peritoneum, diaphragm, and omentum [ 1 ].

    The microscopic finding in the liver of infected deer includes the presence of large quantities of connective tissue that forms wider or narrower stripes that are wound around groups of degenerated and kuklo liver lobuli which are irregular in shape and of unequal size. Connective tissue septa are often seen to contain lymphocytes, macrophages which often contain brown pigment — parasite hematin, which is also present in the parenchyma.

    The bile duct walls are thickened, and desquamated cells, parasite eggs and brown pigment are present in their lumen [ 16 — 9 ]. These changes are somewhat similar to those described in the liver of domestic ruminants in connection swx infection with the big liver fluke Fasciola hepatica.

    In chronic form, changes in infections with F. Liver fibrosis and cirrhosis develop as the ultimate result of chronic liver damage oukloj by F. As it is known, hepatic fibrosis and cirrhosis develop following chronic damage to parenchymatous cells caused by infective agents, toxins, drugs, chemicals, malnutrition, metabolites, and hypoxia [ 14 — 17 ].

    During the process of fibrosis and cirrhosis development, the loss of hepatocytes sexx to fibroblast proliferation and transdifferentiation [ 18 — 27 ]. Accordingly, myofibroblast-dependent progressive fibrogenesis is sustained by at least three main pro-fibrogenic mechanisms: 1 chronic activation of the wound healing response, 2 radical oxygen system and other oxidative stress-related reactive mediators, 3 dearangement of epithelial-mesenchymal interaction and epithelial-mesenchymal transition detected in chronic cholangiopathies [ 2829 z.

    Based on location and immunohistochemical profile three myofibroblasts MF subpopulations were kuklon. These comprise 1 portal or septal MFs, present in the portal areas or in newly formed fibrous septa, 2 interface MFs, present at the interface between parenchyma and stroma of the portal areas or newly formed fibrous septa, and 3 the perisinusoidally located hepatic stellate cells HSCs [ 2228 ].

    All types have fibrogenic potential, but many investigators regard HSCs as the principal fibrocompetent cell in the liver. Depending on the sex site of injury the resulting fibrosis may be restricted to the portal areas, as in most biliary diseases, or kukloj be present in the hepatic parenchyma as seen in chronic kukloj and cirrhosis. Although incompletely understood, the activation or transdifferentiation of MFs is a key event in liver tissue repair.

    The behaviour of hepatic MFs during the process of development of parasitic liver cirrhosis in kukloj with natural infection of fallow deer Dama dama with the giant liver fluke Fascioloides magna is not known.

    This ssex was the reason why the distribution and localization of kuklloj MFs have been described and their role discussed in this paper, in addition to the descriptions of histological characteristics of parasitic liver cirrhosis in fallow deer. Livers of 67 fallow deer of different sex and age have been analyzed in this paper. All the samples in this research were collected from animals that had been shot as part of a program to control the deer population. The material originated from deer shot within sanitary regulations and under veterinarian and biologist supervision in area of Northern Serbia closed to river Danube.

    Sex criteria for the selected deer were: poor condition of the animal, sluggish movement, poorly developed musculature, low representation of fatty tissue, poor hair cover and diarrhoea. After antigen retrieval and inactivation of endogenous peroxidase, kukloj were incubated with appropriate primary antibodies diluted in PBS. In 35 The livers were enlarged, dirty-grey sex colour partialy with black pigment deposits, and with accumulated fibrin on the surface and cystoid formations on the cross-section.

    The identification of the giant liver fluke Fascioloides magna was confirmed also by parasitological analysis. Section of the deer liver, dirty-grey in colour, with accumulated fibrin on the surface and thick-wall cystoid formations on the cross-section and circumscribed deposits of black pigment.

    Connective tissue fibres were present in the form of wide or narrow stripes and they divide the liver parenchyma into pseudolobuli of unequal size and irregular shape. In the multiplied connective tissue stripes, there were numerous blood vessels kukloj thickened walls which contain smooth muscle cells, partly vacuolized, and partly with homogenized cytoplasm.

    Disrupted architecture of the liver with cirrhosis. Connective tissue fibres present in the form of wide or narrow stripes divide the liver parenchyma into pseudolobuli of unequal size and irregural shape asterisk. Deposits of hematin pigment arrowHE. Endothelial cells of the blood vessels were also vacuolized, and sometimes necrotized and they were found free in the lumen.

    In close proximity to the altered blood vessels there was cellular infiltrate comprised of macrophages and eosinophil granulocytes.

    Vacuolized ukkloj cells of the blood vessel asterisk. Cellular infiltrate in the vessel wall comprised of macrophages and eosinophil granulocytes arrowHE. The connective tissue sex contained numerous bile ducts of different diameter and individual epithelial cells similar to the epithelium of bile kulkoj. Bile duct epithelium-like epithelial cells were also seen between hepatocytes.

    Regenerated hepatocytes were organized into pseudolobuli of different size and of kuklloj, most often oval shape, without a central vein. The presence of macrophages filled with brown pigment was d between hepatocytes and in the connective tissue stripes, and the brown pigment was sometimes also seen free in the connective tissue. The wall of certain bile ducts was thickened, and the epithelium proliferated to the form of edematous swelling and mucous metaplasia with a large number of cup-shaped cells.

    In addition to the described changes, a number of the samples were also seen to contain well encapsulated parasite cystoid formations in the liver parenchyma. These cystoid formations were characterised by a thick connective tissue capsule composed of fibroblasts, connective tissue fibers between which macrophage, lymphocytes, eosinophil granulocytes, and a smaller or larger number of cells with brown pigment sex situated.

    Within this connective tissue capsule, there was necrotic detritus, fibrin, brown pigment, and remains of parasites. Close to the cystoid formations, hepatocytes were atrophic, and the liver lobes and pseudolobuli deformed.

    The positive reaction of pericytes and smooth muscle cells of terminal and sublobular venous blood vessels were observed.

    Kukloj the portal triads, a positive reaction was observed in the arterial tunica mediaand slighter positivity was in the walls of the portal veins. These cells were round, oval, spindle-shaped, or irregular in shape, of varying sizes. Most of these cells, kukloj to their morphological and phenotype characteristics, are similar to vascular smooth muscle cells. Elongated immunopositive cells with a poorly developed body and short cytoplasmatic extensions were found on the boundary between fibrotic septa and the surrounding parenchyma.

    The absence of cells positive to both kulloj markers was observed on the periphery of regenerative lobuli that occur in liver cirrhosis. Endothelial cells of liver blood vessels, hepatocytes and bile duct epithelium showed a negative reaction to the examined markers. It was proved that the giant liver fluke is w in the fallow deer population in the territory of Serbia. The finding of this parasite in the fallow deer population represents a threat as the giant liver fluke could spread to domestic sex which reside in close proximity to hunting grounds [ 1457 — 9 ].

    This paper is focused on sex e in the liver of fallow deer kuiloj parasitic cirrhosis caused by the giant liver fluke and the heterogeneity of the hepatic myofibroblast population. The accumulation of extracellular matrix in kukloj liver in the form of narrow or wide stripes, the forming of pseudolobuli and the presence of chronic cellular infiltrate consisting of lymphocytes and macrophages is accompanied by the presence of macrophages filled with parasite hematin and is a consequence of the host blood metabolism process in the parasite.

    Furthermore, the determined cystoid formations localized in the parenchyma and the morphological characteristics of the parasite are confirmation that these are changes caused by the giant liver fluke Kukloj. Concerning the esx that cysts have only occasionally an epithelium covering part of the inner kuiloj the term cystoid formation is more appropriate [ 5 ].

    Livers of several fallow deer were found to contain proliferation of the epithelium of bile ducts which are framed with a large quantity of connective tissue. Hyperplasia of the bile duct epithelium is described sex literature sex infection with F. It is also possible to link the analogous changes found in fallow deer with proline synthesis and secretion on behalf of kujloj parasite F. Vascular changes are a consequence of traumatic phlebitis and increased accumulation of connective tissue.

    The compensatory increased arterial blood inflow leads to hyperplasia and hypertrophy of the tunica media [ sex13 ]. It is possible to explain the increased amount of extracellular matrix, occurring as a consequence of the accumulation of different proteins, during myofibroblast activation, migration and accumulation. The established strong immunopositivity in myofibroblasts of connective tissue stripes, hyperplastic tunica mediaas well as in extravascular smooth muscle sez is viewed by certain authors as a consequence of their role in pathological angiogenesis during the progression of chronic liver damage [ 28 ].

    Our study has shown that hepatic MFs in fallow deer livers are a very heterogenic cell population, both regarding distribution and regarding morphology, similar as in humans and other animal species [ 18 — 27 ]. It is kukloj that, in addition to MFs, other cell populations in the liver, such as damaged hepatocytes, activated Kupffer cells, and endothelial cells of sinusoids, also play a significant part in fibrogenesis [ 28 ].

    The derangement of epithelial-mesenchymal interactions detected in chronic cholangiopathies is most likely the pro-fibrogenic mechanism in liver cirrhosis in fallow deer Dama dama infected with the giant liver fluke Fascioloides magna.

    This is the first publication reporting morphological changes in liver in fallow deer Dama dama in Serbia. Myofibroblasts, especially HSCs, play an important role in the synthesis of extracellular matrix components in the development of parasitic fibrosis and cirrhosis in the liver of fallow deer.

    Activated HSCs, as well as portal and septal myofibroblasts, correlate with the degree of liver fibrosis. Marinkovic D, Nesic V: Changes on the liver of fallow deer Dama dama caused by american giant liver fluke Fascioloides magna. XX Veterinary Meeting of Serbia. Zlatibor: Serbain Veterinary Society, Belgrade; Hackenheim: Conchbooks; — Spakulova M, Corba J, Varady M, Rajsky D: [Bionomy, occurrence and importance of the giant liver fluke Fascioloides magnaan important parasite of free-living ruminants].

    Vet Med. Prague: Academia; J Sex Pathol. Vet Res Commun. Parasitol Res. Belgrade,Serbia; — J Helminthol. Modavi S, Isseroff H: Fasciola hepatica : kukoj deposition and other histopathology in the rat host's bile duct caused by the parasite and by proline infusion. Exp Parasitol. Rushton B, Murray M: Hepatic pathology of a primary experimental infection of Fasciola hepatica in sheep.

    J Clin Invest. Center SA: Chronic liver disease: current sex of disease mechanisms.